Tnks^{Gt(RRC239)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Tnks^{Gt(RRC239)Byg}
• Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; gene trap RRC239, BayGenomics
• MGI ID: MGI:4127087
• Gene: Tnks Location: Chr8:35296333-35432844 bp, - strand Genetic Position: Chr8, 21.16 cM
• Alliance: Tnks^{Gt(RRC239)Byg} page

Mutation origin

• Mutant Cell Line: RRC239
• Germline Transmission: Earliest citation of germline transmission: J:154388
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector containing a beta-geo cassette inserted into intron 1. A less than 5% of wild-type transcript expression level was confirmed by quantitative RT-PCR on epididymal fat pad extracts. (J:154388)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRC239	CC200244 ; (MGI Seq Detail)	5' RACE	Chr8:35432170-35432333 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tnks^Gt(RRC239)Byg/Tnks^Gt(RRC239)Byg	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
adipose tissue	√
decreased epididymal fat pad weight	√
decreased renal fat pad weight	√
behavior/neurological	√
increased food intake	√
cellular	√
increased muscle cell glucose uptake	√
homeostasis/metabolism	√
hypoglycemia	√
increased circulating insulin level	√
decreased circulating leptin level	√
increased circulating ketone body level	√
increased body temperature	√
increased oxygen consumption	√
increased adiponectin level	√
muscle	√
increased muscle cell glucose uptake	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnks Mutation: 79 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)