Dcp2^{Gt(RRE061)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Dcp2^{Gt(RRE061)Byg}
• Name: decapping mRNA 2; gene trap RRE061, BayGenomics
• MGI ID: MGI:4127248
• Synonyms: Dcp2^beta
• Gene: Dcp2 Location: Chr18:44513569-44558036 bp, + strand Genetic Position: Chr18, 23.74 cM, cytoband B3
• Alliance: Dcp2^{Gt(RRE061)Byg} page

Mutation origin

• Mutant Cell Line: RRE061
• Germline Transmission: Earliest citation of germline transmission: J:166846
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The gene trap vector insertion site was mapped to nucleotide 12535 within intron 1 of the Dcp2 gene. Western analysis of several organs from 4-week-old wild-type (WT) and homozygous littermates revealed the mice containing a homozygous insertion of the gene trap vector were not completely devoid of Dcp2 expression and were instead phenotypically hypomorphic with reduced protein expression in the different tissues that Dcp2 can normally be detected. (J:166846)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRE061	CC200417 ; (MGI Seq Detail)	5' RACE	Chr18:44513593-44513749 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  201 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dcp2 Mutation: 39 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)