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EpcamGt(RST556)Byg
Gene trapped Allele Detail
Summary
Symbol: EpcamGt(RST556)Byg
Name: epithelial cell adhesion molecule; gene trap RST556, BayGenomics
MGI ID: MGI:4127613
Gene: Epcam  Location: Chr17:87943407-87958555 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance: EpcamGt(RST556)Byg page
Developmental delay in EpcamGt(RST556)Byg/EpcamGt(RST556)Byg embryos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  RST556
Germline Transmission:  Earliest citation of germline transmission: J:155941
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1TMpfs     Vector Type: secretory trap
 
Mutation detailsA gene trap insertion located in the third intron results in an in frame fusion transcript consisting of exons 1 (untranslated region), 2, and 3, a CD2-derived transmembrane domain, beta galactosidase and neomycin. LacZ expression is detected at E8.5 in a predominantly endodermal pattern and in multiple tissues at later stages. (J:155941)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Generation of the EpcamGt(RST556)Byg allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epcam Mutation:  33 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory