Atad5^{Gt(RRF055)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Atad5^{Gt(RRF055)Byg}
• Name: ATPase family, AAA domain containing 5; gene trap RRF055, BayGenomics
• MGI ID: MGI:4127920
• Synonyms: Atad5^m
• Gene: Atad5 Location: Chr11:79980226-80026620 bp, + strand Genetic Position: Chr11, 47.48 cM
• Alliance: Atad5^{Gt(RRF055)Byg} page

Atad5^{Gt(RRF055)Byg}/Atad5⁺ mice are tumor-prone

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: RRF055
• Germline Transmission: Earliest citation of germline transmission: J:176672
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap inserted into intron 18. A 50% reduction in protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts from heterozygous mice. (J:176672)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRF055	CC249314 ; (MGI Seq Detail)	5' RACE	Chr11:80009790-80014955 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  35 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Insertional mutagenesis to generate the Atad5^{Gt(RRF055)Byg} allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atad5^{Gt(RRF055)Byg}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atad5 Mutation: 100 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)