Ccar2^Gt(XN876)Byg
Gene trapped Allele Detail

Summary

• Symbol: Ccar2^Gt(XN876)Byg
• Name: cell cycle activator and apoptosis regulator 2; gene trap XN876, BayGenomics
• MGI ID: MGI:4129528
• Synonyms: Dbc1^-
• Gene: Ccar2 Location: Chr14:70375613-70391260 bp, - strand Genetic Position: Chr14, 36.24 cM
• Alliance: Ccar2^Gt(XN876)Byg page

Ccar2^Gt(XN876)Byg/Ccar2^Gt(XN876)Byg mice are protected against high fat diet-induced liver steatosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XN876
• Germline Transmission: Earliest citation of germline transmission: J:156677
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The gene targeting vector insertion occurred between exon 6 and exon 7. Absence of protein in the liver was confirmed by western blot. (J:156677)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XN876	CC326480 ; (MGI Seq Detail)	5' RACE	Chr14:70388462-70389335 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ccar2^Gt(XN876)Byg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccar2 Mutation: 40 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 12 reference(s)