Acp1^{Gt(RRK222)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Acp1^{Gt(RRK222)Byg}
• Name: acid phosphatase 1, soluble; gene trap RRK222, BayGenomics
• MGI ID: MGI:4130291
• Synonyms: Acp1^-
• Gene: Acp1 Location: Chr12:30943325-30961588 bp, - strand Genetic Position: Chr12, 13.0 cM
• Alliance: Acp1^{Gt(RRK222)Byg} page

Mutation origin

• Mutant Cell Line: RRK222
• Germline Transmission: Earliest citation of germline transmission: J:227733
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The gene trap inserted into intron 4. Western blot analysis confirmed the absence of protein expression in heart homogenates from 16 week old homozygous mutant mice. Expression was also undetectable by immunoblotting in lysates of liver, skeletal muscle, adipose tissue, and tails. (J:227733)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRK222	CC894090 ; (MGI Seq Detail)	5' RACE	Chr12:30954871-30961530 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Acp1^Gt(RRK222)Byg/Acp1^Gt(RRK222)Byg	C.129P2(B6)-Acp1^Gt(RRK222)Byg

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
cardiovascular system	√
decreased response of heart to induced stress	√
cellular	√
decreased cardiomyocyte apoptosis	√
growth/size/body	√
decreased body weight	√
homeostasis/metabolism	√
decreased response of heart to induced stress	√
muscle	√
decreased cardiomyocyte apoptosis	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acp1 Mutation: 12 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)