Akr1a1^{Gt(OST222400)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Akr1a1^{Gt(OST222400)Lex}
• Name: aldo-keto reductase family 1, member A1; gene trap OST222400, Lexicon Genetics
• MGI ID: MGI:4239556
• Synonyms: GR^-
• Gene: Akr1a1 Location: Chr4:116493707-116508871 bp, - strand Genetic Position: Chr4, 53.26 cM, cytoband C7
• Alliance: Akr1a1^{Gt(OST222400)Lex} page

Severe loss of bone and fractures in the long bones of Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: OST222400
• Germline Transmission: Earliest citation of germline transmission: J:164548
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted upstream of the exon containing the start codon. Protein assay confirmed the absence of glucoronate reducing activity.
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST222400	CG581800 ; (MGI Seq Detail)	3' RACE	Chr4:116496263-116499127 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  86 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Schema for generation of the Akr1a1^{Gt(OST222400)Lex} allele

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akr1a1 Mutation: 31 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)