Hsd17b11^{Gt(OST237628)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Hsd17b11^{Gt(OST237628)Lex}
• Name: hydroxysteroid (17-beta) dehydrogenase 11; gene trap OST237628, Lexicon Genetics
• MGI ID: MGI:4245470
• Gene: Hsd17b11 Location: Chr5:104137631-104169662 bp, - strand Genetic Position: Chr5, 50.52 cM, cytoband E4
• Alliance: Hsd17b11^{Gt(OST237628)Lex} page

Mutation origin

• Mutant Cell Line: OST237628
• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. The Hsd17b11 gene consists of 7 exons. Retroviral insertion disrupted the gene prior to the exon encoding amino acid 55 in a protein of 298 amino acids (NCBI accession number NP_444492). RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (J:171883)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST237628	CG587735 ; (MGI Seq Detail)	3' RACE	Chr5:104166037-104166148 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsd17b11 Mutation: 25 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)