Dpcd/Poll^{Gt(OST280355)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Dpcd/Poll^{Gt(OST280355)Lex}
• Name: deleted in primary ciliary dyskinesia; gene trap OST280355, Lexicon Genetics
• MGI ID: MGI:4262238
• Gene: Dpcd Location: Chr19:45549018-45566728 bp, + strand Genetic Position: Chr19, 38.75 cM
• Alliance: Dpcd/Poll^{Gt(OST280355)Lex} page

Mutation origin

• Mutant Cell Line: OST280355
• Germline Transmission: Earliest citation of germline transmission: J:171184
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Gene trap insertion was in intron 1 of Poll and also the promoter region of Dpcd near the transcriptional start site. These two genes overlap, and the gene trap inserted into this overlapping region. By RT-PCR analysis, no endogenous Poll transcript was detected in homozygous tissues. Similary, no endogenous Dpcd transcript was detected in homozygous tissues. (J:171184)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST280355	CG604541 ; (MGI Seq Detail)	3' RACE	Chr19:45546779-45548153 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  5 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpcd Mutation: 7 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)