Dab2ip^{Gt(OST348452)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Dab2ip^{Gt(OST348452)Lex}
• Name: disabled 2 interacting protein; gene trap OST348452, Lexicon Genetics
• MGI ID: MGI:4289309
• Gene: Dab2ip Location: Chr2:35448285-35621006 bp, + strand Genetic Position: Chr2, 23.74 cM
• Alliance: Dab2ip^{Gt(OST348452)Lex} page

Delayed Purkinje cell dendrite outgrowth in Dab2ip^{Gt(OST348452)Lex}/Dab2ip^{Gt(OST348452)Lex} mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: OST348452
• Germline Transmission: Earliest citation of germline transmission: J:195873
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted into intron 5. Western blot analysis confirmed reduced protein expression of 2 of 3 isoforms in the brain. This allele is hypomorphic. (J:195873)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST348452	CG631677 ; (MGI Seq Detail)	3' RACE	Chr2:35597655-35600063 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  47 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Dab2ip^{Gt(OST348452)Lex} allele

Expression

In Mice Carrying this Mutation:

44 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab2ip Mutation: 56 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)