Rras2^{Gt(OST361011)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rras2^{Gt(OST361011)Lex}
• Name: related RAS viral (r-ras) oncogene 2; gene trap OST361011, Lexicon Genetics
• MGI ID: MGI:4294133
• Synonyms: Rras2^{Gt(OST361011)Lex}, TC21^-
• Gene: Rras2 Location: Chr7:113646017-113717016 bp, - strand Genetic Position: Chr7, 59.29 cM, cytoband F2
• Alliance: Rras2^{Gt(OST361011)Lex} page

Mutation origin

• Mutant Cell Line: OST361011
• Germline Transmission: Earliest citation of germline transmission: J:151653
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. Genetrap vector VICTR27 inserted into intron 1 of the gene locus. Gene inactivation was confirmed by no signal in immunoblot analysis of homozygote thymus extracts. (J:141210, J:151653)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST361011	CG636518 ; (MGI Seq Detail)	3' RACE	Chr7:113647393-113659655 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  23 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rras2 Mutation: 33 strains or lines available

References

• Original: J:151653 Delgado P, et al., Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol. 2009 Aug;10(8):880-8
• All: 10 reference(s)