Trim37^{Gt(RRO307)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Trim37^{Gt(RRO307)Byg}
• Name: tripartite motif-containing 37; gene trap RRO307, BayGenomics
• MGI ID: MGI:4329141
• Synonyms: Trim37^-, Trim37^Gt(bgeo)FH
• Gene: Trim37 Location: Chr11:87017903-87111509 bp, + strand Genetic Position: Chr11, 51.93 cM
• Alliance: Trim37^{Gt(RRO307)Byg} page

Mutation origin

• Mutant Cell Line: RRO307
• Germline Transmission: Earliest citation of germline transmission: J:232482
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The beta-geo gene trap insertion vector inserted in intron 2 of the gene. mRNA expression, quantified by qRT-PCR, was reduced to 0.7-1.0% in brain and to 0.5-3.1% in testis of homozygous mutants compared to control mice. (J:232482)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRO307	CG671703 ; (MGI Seq Detail)	5' RACE	Chr11:87020572-87020641 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trim37^{Gt(RRO307)Byg}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim37 Mutation: 40 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)