Ncor2^{Gt(RRM275)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ncor2^{Gt(RRM275)Byg}
• Name: nuclear receptor co-repressor 2; gene trap RRM275, BayGenomics
• MGI ID: MGI:4329504
• Gene: Ncor2 Location: Chr5:125094217-125256283 bp, - strand Genetic Position: Chr5, 63.96 cM, cytoband F
• Alliance: Ncor2^{Gt(RRM275)Byg} page

High fat diet-fed Ncor2^{Gt(RRM275)Byg}/Ncor2⁺ mice exhibit reduced hepatic steatosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: RRM275
• Germline Transmission: Earliest citation of germline transmission: J:164558
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted between exons 9 and 10. Reduced protein expression was confirmed by western blot analysis on epididymal pad extracts from heterozygous mice. (J:164558)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRM275	CG672090 ; (MGI Seq Detail)	5' RACE	Chr5:125168718-125187107 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  126 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Ncor2^{Gt(RRM275)Byg} allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncor2 Mutation: 170 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)