Hic2^{Gt(RRN127)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Hic2^{Gt(RRN127)Byg}
• Name: hypermethylated in cancer 2; gene trap RRN127, BayGenomics
• MGI ID: MGI:4329590
• Synonyms: Hic2^GT
• Gene: Hic2 Location: Chr16:17051451-17081294 bp, + strand Genetic Position: Chr16, 10.68 cM, cytoband B1
• Alliance: Hic2^{Gt(RRN127)Byg} page

Mutation origin

• Mutant Cell Line: RRN127
• Germline Transmission: Earliest citation of germline transmission: J:225226
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The pGT0Lxf gene trap vector inserted randonmly into intron 2 of the gene. Beta-galalctosidase is expressed under the control of the endogenous promoter. (J:225226)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRN127	CG672180 ; (MGI Seq Detail)	5' RACE	Chr16:17051531-17072928 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hic2 Mutation: 258 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)