Ptpn14^{Gt(RRR484)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ptpn14^{Gt(RRR484)Byg}
• Name: protein tyrosine phosphatase, non-receptor type 14; gene trap RRR484, BayGenomics
• MGI ID: MGI:4330561
• Synonyms: Ptpn14^trap
• Gene: Ptpn14 Location: Chr1:189460465-189608892 bp, + strand Genetic Position: Chr1, 95.03 cM
• Alliance: Ptpn14^{Gt(RRR484)Byg} page

Mutation origin

• Mutant Cell Line: RRR484
• Germline Transmission: Earliest citation of germline transmission: J:169186
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted into intron 5. The allele is predicted to produce a truncated protein at amino acid 170 within the FERM domain. RT-PCR confirmed the leakiness of the gene trap.
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRR484	CG784732 ; (MGI Seq Detail)	5' RACE	Chr1:189519010-189557292 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  75 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn14 Mutation: 60 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)