Klf3^{Gt(XS0187)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Klf3^{Gt(XS0187)Wtsi}
• Name: Kruppel-like transcription factor 3 (basic); gene trap XS0187, Wellcome Trust Sanger Institute
• MGI ID: MGI:4331780
• Synonyms: XS
• Gene: Klf3 Location: Chr5:64960864-64990246 bp, + strand Genetic Position: Chr5, 33.49 cM
• Alliance: Klf3^{Gt(XS0187)Wtsi} page

Thickening of the valve leaflets in Klf3^{Gt(XS0187)Wtsi}/Klf3^{Gt(XS0187)Wtsi} mice with aortic valvular stenosis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XS0187
• Germline Transmission: Earliest citation of germline transmission: J:206507
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxf
• Mutation details: The gene trap vector inserted into intron 2. Western blot analysis confirmed the absence of protein expression in the spleen. (J:206507)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XS0187	CG869828 ; (MGI Seq Detail)	5' RACE	Chr5:64960981-64974172 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  180 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Schematic of the DNA insertion site of the gene trap in Klf3^{Gt(XS0187)Wtsi} and Klf3^{Gt(CH0516)Wtsi} alleles

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klf3 Mutation: 80 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 2 reference(s)