Mto1^{Gt(G019A03)Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Mto1^{Gt(G019A03)Wrst}
• Name: mitochondrial tRNA translation optimization 1; gene trap G019A03, German Gene Trap Consortium
• MGI ID: MGI:4336382
• Gene: Mto1 Location: Chr9:78355372-78381447 bp, + strand Genetic Position: Chr9, 43.65 cM, cytoband E1
• Alliance: Mto1^{Gt(G019A03)Wrst} page

Mutation origin

• Mutant Cell Line: G019A03
• Germline Transmission: Earliest citation of germline transmission: J:223246
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: U3CEO Vector Type: secretory trap
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. The gene trap vector U3CEO inserted into intron 6 of Mto1. Quantitative RT-PCR analysis of mRNA levels in heart from homozygotes indicate a 63% reduction compared to controls, indicating this is a hypomorphic allele. (J:223246)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  G019A03	CL214092 ; (MGI Seq Detail)	5' RACE	Chr9:78364530-78364887 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mto1 Mutation: 37 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)