Kars1^{Gt(AJ0130)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Kars1^{Gt(AJ0130)Wtsi}
• Name: lysyl-tRNA synthetase 1; gene trap AJ0130, Wellcome Trust Sanger Institute
• MGI ID: MGI:4344829
• Synonyms: KRS^-
• Gene: Kars1 Location: Chr8:112720075-112737955 bp, - strand Genetic Position: Chr8, 58.27 cM, cytoband D3
• Alliance: Kars1^{Gt(AJ0130)Wtsi} page

Mutation origin

• Mutant Cell Line: AJ0130
• Germline Transmission: Earliest citation of germline transmission: J:264950
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: Gene disruption was accomplished via the insertion of the gene trap cassette into intron 13. Immunoblot analysis demonstrated overall reduction of protein expression in various organs of heterozygous mutant mice. (J:264950)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AJ0130	CL459445 ; (MGI Seq Detail)	5' RACE	Chr8:112723091-112725243 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  24 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kars1 Mutation: 34 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 2 reference(s)