Pi4k2a^{Gt(AK0094)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Pi4k2a^{Gt(AK0094)Wtsi}
• Name: phosphatidylinositol 4-kinase type 2 alpha; gene trap AK0094, Wellcome Trust Sanger Institute
• MGI ID: MGI:4345401
• Gene: Pi4k2a Location: Chr19:42078909-42110526 bp, + strand Genetic Position: Chr19, 35.74 cM
• Alliance: Pi4k2a^{Gt(AK0094)Wtsi} page

Pi4k2a^{Gt(AK0094)Wtsi}/Pi4k2a^{Gt(AK0094)Wtsi} mice exhibit weakness, tremor, urinary incontinence, limb clasping, and reduced survival

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: AK0094
• Germline Transmission: Earliest citation of germline transmission: J:150794
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: Vector was integrated into intron 2, predicting a fusion protein lacking the catalytic domain, comprising amino acid residues 1-212 and the selectable Beta-geo (LacZ/Neo) cassette. (J:150794)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AK0094	CL525069 ; (MGI Seq Detail)	5' RACE	Chr19:42089188-42089275 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  12 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pi4k2a Mutation: 37 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)