Cers2^{Gt(S16-4B1)Sor}
Gene trapped Allele Detail

Summary

• Symbol: Cers2^{Gt(S16-4B1)Sor}
• Name: ceramide synthase 2; gene trap S16-4B1, Philippe Soriano
• MGI ID: MGI:4346044
• Synonyms: cers2^gt, Lass2^{Gt(FHCRC-GT-S16-4B1)Sor}
• Gene: Cers2 Location: Chr3:95222102-95230910 bp, + strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Cers2^{Gt(S16-4B1)Sor} page

Abnormal morphology of Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor} trigeminal nerve axons

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: S16-4B1
• Germline Transmission: Earliest citation of germline transmission: J:156841
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: The ROSAFARY gene trap vector, which contains a beta-geo cassette, inserted into exon 1. Northern blot analysis confirmed the absence of transcript expression in liver, kidney, and brain extracts. (J:156841)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S16-4B1	CL526263 ; (MGI Seq Detail)	3' RACE	Chr3:95227443-95230565 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  38 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cers2 Mutation: 60 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 27 reference(s)