Ndufs6^{Gt(AR0138)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Ndufs6^{Gt(AR0138)Wtsi}
• Name: NADH:ubiquinone oxidoreductase core subunit S6; gene trap AR0138, Wellcome Trust Sanger Institute
• MGI ID: MGI:4346527
• Synonyms: Ndufs6^gt
• Gene: Ndufs6 Location: Chr13:73467995-73476574 bp, - strand Genetic Position: Chr13, 39.69 cM, cytoband D2
• Alliance: Ndufs6^{Gt(AR0138)Wtsi} page

Myocardial fibrosis and abnormal mitochondrial morphology in Ndufs6^{Gt(AR0138)Wtsi}/Ndufs6^{Gt(AR0138)Wtsi} hearts

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: AR0138
• Germline Transmission: Earliest citation of germline transmission: J:183619
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: The gene trap vector inserted into intron 2. Homozygous mice show decreased protein expression in all tissues examined. (J:183619)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AR0138	CL569742 ; (MGI Seq Detail)	5' RACE	Chr13:73475534-73475608 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  38 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Ndufs6^{Gt(AR0138)Wtsi} allele

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndufs6 Mutation: 14 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)