Ltbp4^{Gt(E301B04)Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Ltbp4^{Gt(E301B04)Wrst}
• Name: latent transforming growth factor beta binding protein 4; gene trap E301B04, German Gene Trap Consortium
• MGI ID: MGI:4352296
• Gene: Ltbp4 Location: Chr7:27004561-27037117 bp, - strand Genetic Position: Chr7, 15.87 cM
• Alliance: Ltbp4^{Gt(E301B04)Wrst} page

Mutation origin

• Mutant Cell Line: E301B04
• Germline Transmission: Earliest citation of germline transmission: J:221200
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: reFROSAbgeo+1s
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. A FlipROSAbetageo gene-trap cassette inserted into the fifth intron of the gene (this is the first intron of the short isoform and the fourth intron of the long isoform). Western blot analysis indicates absence of protein expression (both the short and long isoforms) in the lung, aorta, skin, and heart. (J:221200)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  3SE301B04	FI851725 ; (MGI Seq Detail)	3'Splinkerette PCR	Chr7:27032620-27032654 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  105 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltbp4 Mutation: 120 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)