Tg(Smad7-cre)1Sjc
Transgene Detail

Summary

• Symbol: Tg(Smad7-cre)1Sjc
• Name: transgene insertion 1, Simon J Conway
• MGI ID: MGI:4352679
• Synonyms: Smad7^Cre
• Transgene: Tg(Smad7-cre)1Sjc Location: unknown
• Alliance: Tg(Smad7-cre)1Sjc page

Cardiovascular abnormalities in Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺ Tg(Smad7-cre)1Sjc/0 embryos

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Smad7-cre)1Sjc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Smad7

• Mutation details: A 4.3 kb fragment of the Smad7 promoter was cloned into an expression vector in front of the EGFPcre sequence. The linearized construct was injected into C3H/FeJ zygotes. Two lines were generated that gave similar expression patterns when crossed to the R26R reporter line, and only one line was studied further. (J:150864)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Smad7 (species not specified) Summary of all recombinase alleles driven by Smad7. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:150864 Snider P, et al., Generation of Smad7(-Cre) recombinase mice: A useful tool for the study of epithelial-mesenchymal transformation within the embryonic heart. Genesis. 2009 Jul;47(7):469-75
• All: 1 reference(s)