Antxr2^tm1.2Lepp
Targeted Allele Detail

Summary

• Symbol: Antxr2^tm1.2Lepp
• Name: anthrax toxin receptor 2; targeted mutation 1.2, Stephen H Leppla
• MGI ID: MGI:4352944
• Synonyms: CMG2^-
• Gene: Antxr2 Location: Chr5:98032547-98178876 bp, - strand Genetic Position: Chr5, 47.77 cM, cytoband E3
• Alliance: Antxr2^tm1.2Lepp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150952
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 12, which encodes the transmembrane domain, and an frt flanked neo cassette and second loxP site were inserted downstream of exon 12. Cre mediated recombination then removed exon 12 and (when present) the neo cassette leaving behind a single loxP site. (J:150952)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Antxr2 Mutation: 43 strains or lines available

References

• Original: J:150952 Liu S, et al., Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
• All: 7 reference(s)