Ets2^tm5.1Rgo
Targeted Allele Detail

Summary

• Symbol: Ets2^tm5.1Rgo
• Name: E26 avian leukemia oncogene 2, 3' domain; targeted mutation 5.1, Robert G Oshima
• MGI ID: MGI:4353393
• Synonyms: Ets2^fl, Ets2^LoxP
• Gene: Ets2 Location: Chr16:95503274-95522093 bp, + strand Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
• Alliance: Ets2^tm5.1Rgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151187
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed pgk-neo and HSV-TK cassette was inserted into intron 2 and a single loxP site was inserted into intron 5 via homologous recombination. Cre mediated recombination then removed the selection cassette leaving exons 3, 4 and 5 floxed. (J:151187)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets2 Mutation: 39 strains or lines available

References

• Original: J:151187 Wei G, et al., Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood. 2009 Jul 30;114(5):1123-30
• All: 6 reference(s)