Themis^5AT161
Chemically induced Allele Detail

Summary

• Symbol: Themis^5AT161
• Name: thymocyte selection associated; 5AT161
• MGI ID: MGI:4353412
• Synonyms: Themis(Y489X)
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^5AT161 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A transversion generated a stop codon in place of the sequence encoding a tyrosine residue at position 489. Immunoblot analysis on homozygote thymus extracts detected only a very small amount of truncated protein, and mRNA levels in these extracts were one-third of endogenous levels. (J:151076)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 57 strains or lines available

References

• Original: J:151076 Johnson AL, et al., Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol. 2009 Aug;10(8):831-9
• All: 1 reference(s)