Asic3^tm1Pho
Targeted Allele Detail

Summary

• Symbol: Asic3^tm1Pho
• Name: acid-sensing ion channel 3; targeted mutation 1, Peter Holzer
• MGI ID: MGI:4353615
• Synonyms: ASIC#^-
• Gene: Asic3 Location: Chr5:24618449-24622836 bp, + strand Genetic Position: Chr5, 11.72 cM
• Alliance: Asic3^tm1Pho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin cassette replaced part of exon 1, and all of exons 2-7. Southern blotting confirmed correct targeting took place. (J:151304)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asic3 Mutation: 30 strains or lines available

References

• Original: J:151304 Wultsch T, et al., Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis. Pain. 2008 Feb;134(3):245-53
• All: 4 reference(s)