Cacna2d1^tm1Aschw
Targeted Allele Detail

Summary

• Symbol: Cacna2d1^tm1Aschw
• Name: calcium channel, voltage-dependent, alpha2/delta subunit 1; targeted mutation 1, Arnold Schwartz
• MGI ID: MGI:4353680
• Synonyms: alpha-2/delta-1^-, alpha2/delta-1^-
• Gene: Cacna2d1 Location: Chr5:16139786-16579502 bp, + strand Genetic Position: Chr5, 6.56 cM
• Alliance: Cacna2d1^tm1Aschw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by insertion of a neomycin cassette. Gene inactivation was confirmed by no signal in immunoblot analysis of homozygote heart, brain and skeletal muscle extracts. (J:151101)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cacna2d1 Mutation: 79 strains or lines available

References

• Original: J:151101 Fuller-Bicer GA, et al., Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H117-24
• All: 15 reference(s)