Szt2^Gt(XH662)Byg
Gene trapped Allele Detail

Summary

• Symbol: Szt2^Gt(XH662)Byg
• Name: SZT2 subunit of KICSTOR complex; gene trap XH662, BayGenomics
• MGI ID: MGI:4353996
• Gene: Szt2 Location: Chr4:118219940-118266470 bp, - strand Genetic Position: Chr4, 54.61 cM
• Alliance: Szt2^Gt(XH662)Byg page

Mutation origin

• Mutant Cell Line: XH662
• Germline Transmission: Earliest citation of germline transmission: J:150942
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector was inserted in exon 21. Northern blot analysis indicates an increase in expression of the mutant transcript in whole brains from homozygous mice. (J:150942)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XH662	CC182730 ; (MGI Seq Detail)	5' RACE	Chr4:118246121-118246707 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Szt2 Mutation: 94 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:150942 Frankel WN, et al., Szt2, a novel gene for seizure threshold in mice. Genes Brain Behav. 2009 Jul;8(5):568-76
• All: 4 reference(s)