Pax6^tm1.1Ued
Targeted Allele Detail

Summary

• Symbol: Pax6^tm1.1Ued
• Name: paired box 6; targeted mutation 1.1, University of Edinburgh
• MGI ID: MGI:4354123
• Synonyms: Pax6^loxPdelta
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^tm1.1Ued page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151427
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exons 5, 5a, and 6. The absence of protein expression was confirmed by immunohistochemistry on brain sections. (J:151427)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 94 strains or lines available

References

• Original: J:151427 Simpson TI, et al., Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev. 2009;4:19
• All: 2 reference(s)