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Tg(Ckm-Ppargc1b)T37Brsp
Transgene Detail
Summary
Symbol: Tg(Ckm-Ppargc1b)T37Brsp
Name: transgene insertion T37, Bruce M Spiegelman
MGI ID: MGI:4354127
Synonyms: MCK-PGC-1b, PGC-1b
Transgene: Tg(Ckm-Ppargc1b)T37Brsp  Location: unknown  
Alliance: Tg(Ckm-Ppargc1b)T37Brsp page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-Ppargc1b)T37Brsp expresses 1 gene
 
Mutation detailsA transgenic construct containing the complete mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta gene cDNA, the 4.8kb mouse muscle creatine kinase promoter and the human growth hormone polyadenylation site was injected into fertilized FVB mouse eggs. Three lines were generated. Founder line T37 was subsequently established. Expression of Ppargc1b mRNA is increased 10-fold in the quadriceps, and transgene expression is higher in 'white', glycolytic muscle (EDL, quadriceps, gastrocnemius) than in 'red', oxidative muscle (soleus, heart). (J:118258)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:118258 Arany Z, et al., The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007 Jan;5(1):35-46
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory