Srr^rgsc1872
Chemically induced Allele Detail

Summary

• Symbol: Srr^rgsc1872
• Name: serine racemase; RIKEN Genomic Sciences Center (GSC), 1872
• MGI ID: MGI:4354162
• Synonyms: Rgsc01872, Srr^ochre269, Srr^Y269*
• Gene: Srr Location: Chr11:74797185-74816774 bp, - strand Genetic Position: Chr11, 45.76 cM, cytoband B4
• Alliance: Srr^rgsc1872 page

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion was induced at the start of exon 9 resulting in a nonsense mutation (Tyr269Stop). Western blot analysis indicated absence of protein expression in the brains of homozygous mice. D-serine production assays indicated absence of protein activity in preparations from whole brain, hippocampus, and frontal cortex from homozygous mice. (J:151337)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srr Mutation: 32 strains or lines available

References

• Original: J:151337 Labrie V, et al., Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 1;18(17):3227-43
• All: 7 reference(s)