Fgf21^tm1.1Djm
Targeted Allele Detail

Summary

• Symbol: Fgf21^tm1.1Djm
• Name: fibroblast growth factor 21; targeted mutation 1.1, David J Mangelsdorf
• MGI ID: MGI:4354163
• Gene: Fgf21 Location: Chr7:45263314-45264914 bp, - strand Genetic Position: Chr7, 29.38 cM, cytoband B2
• Alliance: Fgf21^tm1.1Djm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150831
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germline, cre mediated recombination removed exons 1 through 3. The absence of transcript expression was confirmed by RT-PCR or QPCR on liver extracts. The absence of plasma Fgf21 concentrations in fasted mice confirmed the lack of protein expression. (J:150831)

Generation of the Fgf21^tm1Djm and Fgf21^tm1.1Djm alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf21 Mutation: 22 strains or lines available

References

• Original: J:150831 Potthoff MJ, et al., FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8
• All: 37 reference(s)