Tg(Apoe-Fgf21)1Sakl
Transgene Detail

Summary

• Symbol: Tg(Apoe-Fgf21)1Sakl
• Name: transgene insertion 1, Steven A Kliewer
• MGI ID: MGI:4354167
• Synonyms: Tg(Fgf21)
• Transgene: Tg(Apoe-Fgf21)1Sakl Location: unknown
• Alliance: Tg(Apoe-Fgf21)1Sakl page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Apoe-Fgf21)1Sakl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fgf21 (MGI:1861377)

• Mutation details: The mouse promoter was used to drive liver-specific expression of the mouse cDNA. Two lines were created (1 and 2) that result in 50-fold, and 150-fold, respectively, higher expression of the transcript compared to in wild-type mice. The two lines exhibit virtually identical changes in fasting serum beta-hydroxybutyrate, triglyceride, total cholesterol, glucose, and insulin concentrations. Line 1 was selected as the representative line. (J:129855)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:129855 Inagaki T, et al., Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21. Cell Metab. 2007 Jun;5(6):415-25
• All: 18 reference(s)