Itga4^tm1Leg
Targeted Allele Detail

Summary

• Symbol: Itga4^tm1Leg
• Name: integrin alpha 4; targeted mutation 1, Lawrence E Goldfinger
• MGI ID: MGI:4354168
• Synonyms: S⁹⁸⁸
• Gene: Itga4 Location: Chr2:79085770-79163467 bp, + strand Genetic Position: Chr2, 47.38 cM
• Alliance: Itga4^tm1Leg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151371
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A single Ser-to-Ala point mutation was created at position 988 (S988A), and a neo cassette flanked by loxP sequences was introduced between exon 27 and exon 28. (J:151371)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga4 Mutation: 62 strains or lines available

References

• Original: J:151371 Goldfinger LE, et al., Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res. 2008 Jul 18;103(2):177-85
• All: 3 reference(s)