Tg(Tyr-BRAF*V600E)476Fgh
Transgene Detail

Summary

• Symbol: Tg(Tyr-BRAF*V600E)476Fgh
• Name: transgene insertion 476, Frank G Haluska
• MGI ID: MGI:4354193
• Transgene: Tg(Tyr-BRAF*V600E)476Fgh Location: unknown
• Alliance: Tg(Tyr-BRAF*V600E)476Fgh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tyr-BRAF*V600E)476Fgh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BRAF (673)

  Braf	(MGI:88190)

  Transgene codes for a protein with a valine to glutamic acid mutation.

• Mutation details: The mouse promoter was used to drive melanocyte-specific expression of the human cDNA containing the amino acid substitution of glutamic acid for valine at position 600 (V600E). This cDNA was cloned from a melanoma line. Four founders were generated and two lines examined (470 and 476). Line 470 exhibits a 3-fold high transcript expression compared to line 476. (J:151455)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:151455 Goel VK, et al., Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene. 2009 Jun 11;28(23):2289-98
• All: 3 reference(s)