Dlg1^tm1.2Agri
Targeted Allele Detail

Summary

• Symbol: Dlg1^tm1.2Agri
• Name: discs large MAGUK scaffold protein 1; targeted mutation 1.2, Anne Griep
• MGI ID: MGI:4354833
• Synonyms: Dlg-1^-
• Gene: Dlg1 Location: Chr16:31482261-31692174 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Dlg1^tm1.2Agri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151538
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: downstream of exon 8 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 8. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:151538)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg1 Mutation: 76 strains or lines available

References

• Original: J:151538 Rivera C, et al., Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis. Dev Dyn. 2009 Jul 21;238(9):2292-2308
• All: 3 reference(s)