Dtx1^tm1.2Mzl
Targeted Allele Detail

Summary

• Symbol: Dtx1^tm1.2Mzl
• Name: deltex 1, E3 ubiquitin ligase; targeted mutation 1.2, Ming-Zong Lai
• MGI ID: MGI:4355029
• Gene: Dtx1 Location: Chr5:120818267-120849992 bp, - strand Genetic Position: Chr5, 60.64 cM
• Alliance: Dtx1^tm1.2Mzl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151605
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A Frt-flanked neomycin cassette and a loxP site were placed downstream of exon 3. An additional loxP site was placed upstream of exon 3. Exon 3 and the neomycin cassette were deleted from the germline by crossing founder mice with cre-transgenic mice. Protein was undetectable in homozygote splenic lymphocytes as determined by immunoblot analysis. (J:151605)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtx1 Mutation: 36 strains or lines available

References

• Original: J:151605 Hsiao HW, et al., Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. Immunity. 2009 Jul 17;31(1):72-83
• All: 3 reference(s)