Klf2^tm2Ling
Targeted Allele Detail

Summary

• Symbol: Klf2^tm2Ling
• Name: Kruppel-like transcription factor 2 (lung); targeted mutation 2, Jerry B Lingrel
• MGI ID: MGI:4355063
• Synonyms: Klf2^fl
• Gene: Klf2 Location: Chr8:73072906-73075498 bp, + strand Genetic Position: Chr8, 34.99 cM, cytoband C1
• Alliance: Klf2^tm2Ling page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151604
• Parent Cell Line: Duffy (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into introns 1 and 2 of the gene locus (J:151604, J:212516)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf2 Mutation: 12 strains or lines available

References

• Original: J:151604 Weinreich MA, et al., KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009 Jul 17;31(1):122-30
• All: 24 reference(s)