Ikzf2^tm1Kast
Targeted Allele Detail

Summary

• Symbol: Ikzf2^tm1Kast
• Name: IKAROS family zinc finger 2; targeted mutation 1, Philippe Kastner
• MGI ID: MGI:4355173
• Synonyms: Helios^-
• Gene: Ikzf2 Location: Chr1:69570373-69726404 bp, - strand Genetic Position: Chr1, 34.9 cM
• Alliance: Ikzf2^tm1Kast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151553
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin cassette replaced the segment of exon 7 that lies between SalI and XbaI restriction sites. This mutation deleted sequences that encode the C-terminal zinc finger domains. The locus produced truncated mRNA as determined by RT-PCR. No protein was detected in immunoblot analysis of homozygote thymus extracts using an antibody specific to the N-terminal of the protein. (J:151553)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf2 Mutation: 41 strains or lines available

References

• Original: J:151553 Cai Q, et al., Helios deficiency has minimal impact on T cell development and function. J Immunol. 2009 Aug 15;183(4):2303-11
• All: 8 reference(s)