Klk4^tm1.1Jpsi
Targeted Allele Detail

Summary

• Symbol: Klk4^tm1.1Jpsi
• Name: kallikrein related-peptidase 4 (prostase, enamel matrix, prostate); targeted mutation 1.1, James P Simmer
• MGI ID: MGI:4355346
• Synonyms: Klk4^lacZ
• Gene: Klk4 Location: Chr7:43530584-43535228 bp, + strand Genetic Position: Chr7, 28.35 cM
• Alliance: Klk4^tm1.1Jpsi page

Abnormal dental enamel of Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi incisors

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151626
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning the initiation codon in exon 2 through exon 6 was replaced with an NLS-lacZ and floxed neo cassette. The neo cassette was subsequently removed by germ line, cre mediated recombination. This allele lacks the entire coding region. (J:151626)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Klk4 Mutation: 21 strains or lines available

References

• Original: J:151626 Simmer JP, et al., Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. J Biol Chem. 2009 Jul 10;284(28):19110-21
• All: 8 reference(s)