Decr1^tm1Jkh
Targeted Allele Detail

Summary

• Symbol: Decr1^tm1Jkh
• Name: 2,4-dienoyl CoA reductase 1, mitochondrial; targeted mutation 1, J Kalervo Hiltunen
• MGI ID: MGI:4355415
• Synonyms: Decr^-
• Gene: Decr1 Location: Chr4:15917240-15945377 bp, - strand Genetic Position: Chr4, 6.66 cM, cytoband A2
• Alliance: Decr1^tm1Jkh page

Fasted Decr1^tm1Jkh/Decr1^tm1Jkh mice show accumulation of lipids in the liver

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151622
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver, muscle, and heart extracts. (J:151622)

Generation of the Decr1^tm1Jkh allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Decr1 Mutation: 26 strains or lines available

References

• Original: J:151622 Miinalainen IJ, et al., Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. PLoS Genet. 2009 Jul;5(7):e1000543
• All: 2 reference(s)