Trp63^tm1Elrf
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1Elrf
• Name: transformation related protein 63; targeted mutation 1, Elsa R Flores
• MGI ID: MGI:4355527
• Synonyms: TAp63^fl
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1Elrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151638
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Modified isoform(s), No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted into intron 2. This creates a conditional-ready allele with exon 2, used for the TA isoforms, floxed. (J:151638)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:151638 Su X, et al., TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009 Jul 2;5(1):64-75
• All: 4 reference(s)