Crtc2^tm1.1Khk
Targeted Allele Detail

Summary

• Symbol: Crtc2^tm1.1Khk
• Name: CREB regulated transcription coactivator 2; targeted mutation 1.1, Klaus H Kaestner
• MGI ID: MGI:4355660
• Gene: Crtc2 Location: Chr3:90161475-90171432 bp, + strand Genetic Position: Chr3, 39.21 cM, cytoband F2
• Alliance: Crtc2^tm1.1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removes exons 4 through 11. The absence of protein expression was confirmed by western blot analysis on liver extracts of fed and fasted mice. (J:151618)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crtc2 Mutation: 27 strains or lines available

References

• Original: J:151618 Le Lay J, et al., CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab. 2009 Jul;10(1):55-62
• All: 1 reference(s)