Ikbkg^tm1.1Chtr
Targeted Allele Detail

Summary

• Symbol: Ikbkg^tm1.1Chtr
• Name: inhibitor of kappaB kinase gamma; targeted mutation 1.1, Christian Trautwein
• MGI ID: MGI:4355682
• Synonyms: Nemo^Fl
• Gene: Ikbkg Location: ChrX:73436896-73497460 bp, + strand Genetic Position: ChrX, 38.0 cM
• Alliance: Ikbkg^tm1.1Chtr page

Ikbkg^tm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0 mice are protected from anti-Fas mAb stimulated development of hepatitis

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151485
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:151485)

Generation of the Ikbkg^tm1.1Chtr allele

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkg Mutation: 16 strains or lines available

References

• Original: J:151485 Beraza N, et al., Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage. J Exp Med. 2009 Aug 3;206(8):1727-37
• All: 16 reference(s)