Tg(Lhx6-icre)1Kess
Transgene Detail

Summary

• Symbol: Tg(Lhx6-icre)1Kess
• Name: transgene insertion 1, Nicoletta Kessaris
• MGI ID: MGI:4355717
• Synonyms: Lhx6-Cre, Lhx6^Cre, Tg(Lhx6-cre)1Kess
• Transgene: Tg(Lhx6-icre)1Kess Location: unknown
• Alliance: Tg(Lhx6-icre)1Kess page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lhx6-icre)1Kess expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lhx6 (MGI:1306803)

• Mutation details: Homologous recombination in bacteria was used to modify a 235Kb BAC RP24-384G1 containing 137 Kb upstream and 80 Kb downstream of the Lhx6 gene. An icre (improved cre) coding sequence was fused to the ATG of Lhx6 in exon 1 using a PCR-based approach. An SV40 polyA was inserted downstream of iCre. The construct was designed to delete the coding sequence of exon 1, as well as the first 80 bp from the first intron. Mice were generated by pronuclear injection of the construct into fertilized oocytes. No line number is given. (J:154447)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lhx6 (mouse) Summary of all recombinase alleles driven by Lhx6. Comparative matrix view of recombinase activities Alliance mouse Lhx6 gene page

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:125700 Fogarty M, et al., Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. J Neurosci. 2007 Oct 10;27(41):10935-46
• All: 56 reference(s)