Tank^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tank^tm1Aki
• Name: TRAF family member-associated Nf-kappa B activator; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:4355741
• Gene: Tank Location: Chr2:61408929-61484515 bp, + strand Genetic Position: Chr2, 35.56 cM
• Alliance: Tank^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151757
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame encoded in exons 3 and 4 were replaced by a neomycin resistance cassette. Expression of mRNA and protein from the locus was abrogated as determined by Northern and Western analysis on homozygote macrophage extracts. (J:151757)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tank Mutation: 30 strains or lines available

References

• Original: J:151757 Kawagoe T, et al., TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol. 2009 Sep;10(9):965-72
• All: 7 reference(s)