Trex2^tm1.2Coso
Targeted Allele Detail

Summary

• Symbol: Trex2^tm1.2Coso
• Name: three prime repair exonuclease 2; targeted mutation 1.2, Concepcio Soler
• MGI ID: MGI:4355746
• Gene: Trex2 Location: ChrX:72477311-72478949 bp, - strand Genetic Position: ChrX, 37.31 cM, cytoband A6
• Alliance: Trex2^tm1.2Coso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151766
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on skin extracts. (J:151766)

Tumor Data

List all tumor models in MMHCdb carrying Trex2^tm1.2Coso

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trex2 Mutation: 2 strains or lines available

References

• Original: J:151766 Parra D, et al., Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice. Cancer Res. 2009 Aug 15;69(16):6676-84
• All: 3 reference(s)