Etv6^{tm1(RUNX1)Haho}
Targeted Allele Detail

Summary

• Symbol: Etv6^{tm1(RUNX1)Haho}
• Name: ets variant 6; targeted mutation 1, Hanno Hock
• MGI ID: MGI:4355899
• Synonyms: TEL-AML1
• Gene: Etv6 Location: Chr6:134012663-134247121 bp, + strand Genetic Position: Chr6, 64.58 cM, cytoband G2
• Alliance: Etv6^{tm1(RUNX1)Haho} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151639
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were replaced with a floxed neo, floxed STOP, and human RUNX1 coding region. When the floxed neo and STOP cassette are removed by cre-mediated recombination, a fusion product of mouse Etv6 and human RUNX1 (or TEL-AML1) was created. (J:151639)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Etv6 Mutation: 144 strains or lines available

References

• Original: J:151639 Schindler JW, et al., TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 2;5(1):43-53
• All: 2 reference(s)