Il23r^tm1.1Kuch
Targeted Allele Detail

Summary

• Symbol: Il23r^tm1.1Kuch
• Name: interleukin 23 receptor; targeted mutation 1.1, Vijay K Kuchroo
• MGI ID: MGI:4355925
• Gene: Il23r Location: Chr6:67399916-67468839 bp, - strand Genetic Position: Chr6, 30.85 cM
• Alliance: Il23r^tm1.1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151907
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin cassette and an IRES-EGFP cassette replaced some of the coding sequence of the gene locus. Cre mediated recombination removed the neomycin resistance gene. Homozygous mice lack expression of the IL-23 receptor. (J:151907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23r Mutation: 69 strains or lines available

References

• Original: J:151907 Elyaman W, et al., IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12885-90
• All: 3 reference(s)